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Cajun Chicken Pasta

Ultimate Cajun Chicken Pasta Recipe (Ready in 25 Minutes!)

This creamy, spicy cajun chicken pasta features tender, seasoned chicken breast tossed with penne in a rich cream sauce loaded with colorful bell peppers and bold Cajun spices. Ready in just 25 minutes, this restaurant-quality dish delivers intense flavor with minimal effort. Perfect for busy weeknights or impressive enough for entertaining, it’s comfort food at its finest.

  • Total Time: 25 minutes
  • Yield: 6 servings

Ingredients

For the Chicken:

  • 1.5 pounds boneless, skinless chicken breasts
  • 2 tablespoons Cajun seasoning
  • 1 tablespoon olive oil
  • Salt and black pepper to taste

For the Pasta and Sauce:

  • 1 pound penne pasta
  • 2 tablespoons butter
  • 1 small onion, diced
  • 1 red bell pepper, thinly sliced
  • 1 yellow bell pepper, thinly sliced
  • 4 cloves garlic, minced
  • 1 tablespoon Cajun seasoning
  • 1/2 teaspoon smoked paprika
  • 1/4 teaspoon cayenne pepper (optional)
  • 1 cup chicken broth
  • 2 cups heavy cream
  • 1/2 cup grated Parmesan cheese
  • 1 teaspoon dried oregano
  • 1/2 teaspoon dried thyme
  • Fresh parsley for garnish

Instructions

  • Prep chicken: Pat chicken dry, pound to even thickness, and season generously with 2 tablespoons Cajun seasoning on both sides.
  • Sear chicken: Heat olive oil in a large skillet over medium-high heat. Cook chicken 5-6 minutes per side until golden and internal temperature reaches 165°F. Remove and let rest.
  • Cook pasta: Boil salted water and cook penne until al dente, about 10 minutes. Reserve 1 cup pasta water before draining.
  • Sauté vegetables: In the same skillet, melt butter and sauté onion and bell peppers for 4-5 minutes. Add garlic, Cajun seasoning, paprika, oregano, thyme, and cayenne; cook 30 seconds.
  • Make sauce: Add chicken broth and simmer 1-2 minutes. Reduce heat to medium-low, add heavy cream, and simmer 3-4 minutes until thickened. Stir in Parmesan.
  • Combine: Slice rested chicken. Add drained pasta to sauce and toss to coat. Top with sliced chicken.
  • Serve: Garnish with fresh parsley and extra Parmesan. Serve immediately with lemon wedges.

Notes

  • Spice level: Adjust Cajun seasoning and cayenne to taste. Start with less for milder versions.
  • Chicken alternatives: Thighs work beautifully and stay more moist. Rotisserie chicken saves time but sacrifices some flavor.
  • Pasta shapes: Penne, fettuccine, rigatoni, or bow ties all work well.
  • Lighter version: Use half-and-half instead of heavy cream and increase vegetables while reducing pasta.
  • Protein additions: Add shrimp during the last 3-4 minutes, or use half chicken and half andouille sausage.
  • Make ahead: Prep vegetables and season chicken up to 24 hours ahead. Cook pasta and sauce fresh for best results.
  • Storage: Refrigerate in airtight container for 3-4 days. Reheat gently with added liquid to prevent drying.
  • Author: Emy Hayer
  • Prep Time: 10 minutes
  • Cook Time: 15 minutes
  • Category: Main Dishes
  • Method: Stovetop, Sautéed
  • Cuisine: American
  • Diet: Low Calorie